During an appearance on The Dan Wootton Interview, Alley admitted that she and Travolta "sort of fell in love with each other" on the set of Look Who's Talking. She was married at the time, so nothing happened, but the feeling was mutual. "I will say it's one of the hardest things I've ever done, the hardest decision I've ever made because I was madly in love with him — we were fun and funny together," she admitted (via ET).

Alley added, "I think there are things that are way worse than sexual relationships, than cheating on someone that way. I consider what I did even worse because I actually let myself fall in love with him and stay in love with him for a long time." She continued to flirt even after Travolta wed Preston, in 1991, leading the actress to confront Alley. "And that was pretty much the end of that," she acknowledged. Thankfully, it led to the trio becoming lifelong friends, something Alley is incredibly grateful for.